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 hypersensitivity type IV  




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WHY ARE SOME DISEASES CLASSIFIED AS TYPE 4 HYPERSENSITIVIES & AT THE SAME TIME HAVE AUTOANTIBODIES? (WHICH WOULD APPEAR AS CLASS 2)
Answer=
Hashimoto thyroiditis, Type I diabetes mellitus & Guillain Barre syndrome are classified as type IV pathologies in which autoantibodies are present and used as clinical markers.

Nevertheless T lymphocytes are responsible for injuring the tissue by DTH or directly killing target cells.

Th1 lymphocytes > IFN γ > ⊕Macrophages > tissue damage




I got a hard time w/ this type of hypersensitivty



Edited by juanlink on Sep 24, 2015 - 12:38 PM




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