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 Epinephrine potentiates diazepam  




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Dear Friends! Please discuss abstract of my new article
Your sserdyuk

S. Е. Serdyuk, V. Е. Gmiro. ADRENALINE POTENTIATES ANTIEPILEPTIC BUT NOT SEDATIVE ACTION OF DIAZEPAM IN RATS. Institute of Experimental Medicine of RAMS, 197376, St. Petersburg, Acad. Pavlov St., 12, Russia; e-mail: gmiro2119@gmail.com.
Intramuscular (i.m.) administration of diazepam in a dose of 10 mg/kg and adrenaline in a dose of 0.2 mg/kg prevents generalized clonic-tonic pentylenetetrazol (PTZ) seizures in 75—80 % of rats, but only in 35—40 % of rats it prevents local clonic PTZ seizures. In the above mentioned do¬se, diazepam causes a strong sedation, but adrenaline does not cause a sedative effects. The combined administration of diazepam and adrenaline in threshold independently ineffective doses prevents both clonic-tonic and clonic PTZ seizures in 80 % of rats without a sedation development. The basis for mechanism of potentiation of anticonvulsant action of diazepam is the stimulation of gastric mucosa vagal afferents by adrenaline.
Key words: adrenalin, diazepam, afferents, stomach, seizure.
RUSSIAN JOURNAL OF PHYSIOLOGY. V. 98. N 2. P. 236—241. 2012






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