mjl1717
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Whats the MOA or the second messenger system for alpha 1 and alpha 2 receptors.?
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| mjl1717
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Cmon guys-This is considered and easy q!
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| mani
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alpha1 - IP3/DAG
alpha2 - Gi -decreased cAMP
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| mjl1717
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I say it like this: (because there is no easy way in this field)
Alpha 1-Gq stimulates phospholipase C :arrow: DAG,IP3 and Calcium2+
:arrow: Protein kinase C (for vasopressin also)
Alpha 2 -Gi inhibits adenyl cyclase :arrow: decreased cAMP :arrow: decreased Protein kinase A (for alpha 2 and beta)
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| Mars-Aris
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similar is with muscarinic receptors
M1 , M3 are as a1 receptors ("excitatory actions")
M2 , a2 ("inhibitory actions") --> inhibit adenylate cyclase
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| H.of.Troy
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in addition like a1 receptors are angiotensinII rec.,several opioids rec. +5HTsubtypes too. :!:
as for a2 rec similar to them are D2rec.too 
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| doctor_tanya23
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hi hws add me in messenger.
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