phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
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please explain for me why Thalassemia reduce the severity of sickle cell disease
thanks
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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In thallasemia beta chains are being less formed.....and so the normal hemoglobin(alpha2,beta2) are decreased.The body finds new avenues to make hemoglobin.....hemoglobin A2(i'm not sure what chains are seen here is it alpha2,delta2???) and fetal hemoglobin(alpha2,gamma2).
In sickle cell anemia the defect is seen in the beta chains(substitution of valine for glutamic acid in 6th position of beta chain)....causing abnormal hemoglobin known as Hemoglobin s which causes sickling to happen)........if thallasemia were to be seen with sickle cell sickle cell's severity will be less because no beta chains to form the abnormal HbS.
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| mani
Forum Guru
Topics: 104
Posts: 1,403
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agree with Malaysian, u have mentioned correct chains for Hb
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