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 Question about lysome enzymes  




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  #1

I remember seeing this question but never got a clear answer. It was a person who was found to have a lot of lysosomal enzymes in his serum. They were wondering what was the cause of that. I think it was a mannose defect or something. Can anyone help?


  #2

I think it is this disease : I cell disease

http://en.wikipedia.org/wiki/I-cell_disease

the problem is in an enzyme that adds mannose to lysosomal enzymes, thereby marking them for transport to lysosomes from golgi apparatus rather than being transferred to outside the cell. this results in a lysosomal storage disease with elevated serum lysosomal enzymes.







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