mash
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wat is the most common specific chromosomal anomaly causing spontaneous abortion?
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| mjl1717
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1) 45X- (only 1% of all 45 X zygotes ever reach term)
2)as a group trisomics-with trisomy 16 the most common
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| PsychDr2B
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In spontaneous abortions, the majority of chromosomal anomalies (95%) are numerical. About 60% are trisomies. 47,XX+16 (trisomy 16) is the most common trisomy associated with spontaneous abortion. Recurrence risk for chromosomal anomaly in subsequent pregnancy is 1% or less. A further 20% are found to have 45,X (Turner's syndrome). Interestingly, approximately 99% of fetuses with 45,X are expelled spontaneously. Another 15% have polyploidy, especially triploidy.
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| PsychDr2B
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Please follow this link for some karyotypes illustrating this topic:
http://www.asklenore.com/miscarriage/print/bickp.html
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