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daily topic discussion

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12 Posts

Misrati

Forum Junior

Topics: 43
Posts: 610

May 18, 2011 - 7:55 AM

Good day every body...how about we share some useful discussions in some important topics. every ones opinion matters, thats how we learn from each other and improve our knowledge.

I'd suggest today we discuss Hematology & Oncology topics or points that any one has question about, so we share our knowledge and opinions.

your participation matters to all. please feel free to ask or write about any thing in the related system. we'll enjoy your company.

thank you.

Prep4USMLE.com

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.Mia.

_________

Topics: 29
Posts: 502

May 18, 2011 - 12:50 PM

Hello Misrati,

Great idea ! I will try come and discuss, as my head is full of confusion sometimes ..... hope more people will join .

Misrati

Forum Junior

Topics: 43
Posts: 610

May 18, 2011 - 3:11 PM

Thanks Mia for stopping by and being my first guest. lookin to see u soon.

OK, let's start by this...

Hematology CHEMO?

the Chemo courses for hematological malignancies. I guess we dont have to memorize them all by heart, but at least we should be aware of the main regimes and the unique ones, also the important side effects of the drugs.

any volunteer for this?

.Mia.

_________

Topics: 29
Posts: 502

May 18, 2011 - 4:24 PM

I'm not good at this, but here is something what I know.

Multiple myeloma. Younger, means less than 65 yo--> autologous BM transplant.
Older , more than 65 --> Melphalan, Thalidomide.

Hodgkin : ABVD
NonHodgkin : CHOP

Chronic ML : Imatinib

Chronic LL : stage 0 when lymphocytosis ,stage 1when only LAD - dont treat .

From acute leukemia what I recall :

is for M3 -- > ATRA

don't remeber now more....

On May 18, 2011 - 7:59 PM, Misrati responded:
you are doin GREAT my friend! I never recall them!

.Mia.

_________

Topics: 29
Posts: 502

May 18, 2011 - 4:26 PM

Now I don't know , in CLL is it also lymphadenopathy when you don't treat ?
I know that it is lymphocytosis when you don't treat.

On May 18, 2011 - 8:14 PM, Misrati responded:
CORRECT

R of CLL

stage 0-2 + asymptomatic = Observation.

symptomatic and/or stages 3-4 = Fludarabine +- Rituximab

Relapse/failure = Pentostatin, alemtuzumab

NO BMT cuz these patients are old.

R for AHA = Steroids.

Misrati

Forum Junior

Topics: 43
Posts: 610

May 18, 2011 - 7:48 PM

Great Mia, Im not good at those either but here I add what I've just learned

AML

Induction therapy (Cytarabine + Daunorubicin)

if remission achieved, high dose consolodation therapy with Cytarabine or BMT
if remission NOT achieved then repeat the course

still not achieved (after 2 cycles) -----> BMT

any relapse after complete remission ------>BMT

No BMT available or patient older than 65 yo consider Gentuzamab

for M3-------> ATRA + Daounrubicin

Consolidation therapy for M3 ----> Cytarabine + Dounrubicin

Misrati

Forum Junior

Topics: 43
Posts: 610

May 19, 2011 - 6:30 AM

CML chemotherapy

Best initial therapy---------> Imatinib (Gleevec): BCR/ABL tyrosine kinase Inhibitor.

No response---------> dasatinib or linotinib, consider BMT

AML blast crisis------> cytarabine + daunorubicin + imatinib followed by BMT

Interferon NEVER the right answer (old school) it takes one year to achiever 10-20% remission only.

Misrati

Forum Junior

Topics: 43
Posts: 610

May 19, 2011 - 6:55 AM

ALL

Induction therapy (VPDA) Vincristine, Prednisone, daounrubicin & asparaginase.

Consolidation R; Cytarabine + daounrubicin.

Maintenance therapy: Methotroxate and/or 6-MP

CNS Prophylaxis: intrathecal Methotrexate.

CLL

stage 0-2 + asymptomatic = Observation.

symptomatic and/or stages 3-4 = Fludarabine +- Rituximab

Relapse/failure = Pentostatin, alemtuzumab

NO BMT cuz these patients are old.

R for AHA = Steroids.

xenopus

Forum Junior

Topics: 15
Posts: 646

May 31, 2011 - 8:03 AM

Hairy cell leukemia is characterized by TRAP positive blasts (Tartrate Resistant Acid Phosphate); dry tap due to bone marrow fibrosis and the treatment is Cladribine (2CdA or 2-ChlorodeoxyAdenosine).

On May 31, 2011 - 9:15 AM, Misrati responded:
thats a cool one. gracias smiling face

shw_pure

Forum Newbie

Topics: 7
Posts: 124

Jun 09, 2011 - 5:54 AM

#10

aplastic anaemia:
Rx:

if bone marrow transplant possible do it (wen pt young n healthy to withstand)

no BMT possible-- immuniosuppressive therapy with
1.antithymocyte globulin
2.cyclosporine
3.prednisone

On Jun 09, 2011 - 8:39 AM, Misrati responded:
thanks a lot Shw. keep it up!

webpath

Forum Newbie

Topics: 5
Posts: 74

Jun 09, 2011 - 6:11 AM

#11

WOW!!! M GONA NOTE DIS ON PAPER ND WILL FIX IT ON D WALL IN FRONT OF ME!!! SO DAT I CAN FIX IT IN MY BRAIN AS WELL.. sticking out tongue