haversian system
Forum Newbie
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hello all!
For diabetes insipidus, FA has indomethacin listed as one of the drugs used to treat nephrogenic DI, along with hydrochlorothiazide and amiloride. The latter 2 make sense to me, but can anyone explain why indomethacin would be appropriate for DI, considering its a cyclooxygenase inhibitor?
Just curious. Thanks!
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| mjl1717
Forum Hero
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It may involve a decrease in GFR, an increase in medullary solute concentration and /or enhanced proximal reabsorption.
There is some speculation with the above
Also with partially intact V2 receptor activation it can enhance the effects of vasopressin on the principal cells of the collecting duct.
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| Idiopathic
Forum Guru
Topics: 19
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indomethacin inhibits the formation of PGE2, which is responsible for vasodilation of the afferent arteriole. The end-result is vasoconstriction, and a decreased GFR, leading to stimulation of proximal reabsorption.
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