namf
Forum Elite
Topics: 80
Posts: 312
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Vaccines against H flu type B prepared with capsular polysaccharides are not effective in young children. If you conjugate the capsular polysaccharides to one of several proteins, the vaccine gets a much better response. Why?
Thanks y'all!
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| mani
Forum Guru
Topics: 104
Posts: 1,403
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very young chlidren dont form antibodies very well esp to nonpeptide molecules. so if capsular polysacharaide is conjugated to a prot, antibody formation is increased
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| doc_rajan
Forum Newbie
Topics: 4
Posts: 26
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Good question namf..
All I've read is that the coupling makes it a T-cell dependent vaccine somehow..
This maybe because due to aggregation, the antigen is no longer soluble and becomes particulate.. and the body reacts by CMI against particulate antigens. The CMI is long lasting because of memory cells..
The latter part is my own supposition.. Any references are welcome
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| Dr. Hussam
Forum Junior
Topics: 5
Posts: 56
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the reason is that to mount an immune response against the incoming Ag, this Ag should be presented on MHC II on antigen presenting cells, MHC II only binds to peptides, not polysaccharide, that's why the antigen won't be presented, so no immune response.
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