BumbleB
Forum Junior
Topics: 2
Posts: 83
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i'm not sure what exactly you're looking for?
obviously dna pol makes dna, rna pol makes rna, zinc fingers are dna bindng domains of certain transcription factors, shh gene is involved in holoprosencephaly, basal cell carcinomas and its a regulator of fork head box (FOX) protein which are also transcription factors...
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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BumbleB pls. tell me you answered the SHH gene bit after checking up in the book!!!Sometimes some of you guys in this forum scare me so much because your answers are so perfect and just know too much.
And what is holoprosencephaly is it a patholigcal condition or some embroyological structure??
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| BumbleB
Forum Junior
Topics: 2
Posts: 83
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Actually, we just learned about the SHH gene in genetics a about 2 weeks ago so it was still in my mind - and I remembered that its involved in holoprosencephaly, but I only learned about its role in basal cell carcinomas after I looked it up in a book.
Holoprocencephaly is neurological congenital abnormality that can show very variable expressivity but if you ever see a CT scan where the brain looks like a figure 8 (big dilated lat ventricles, no gyri or sulci) and then you have a baby with some birth abnormalities (especially cyclopism, etc.) that's what you're seeing.
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| BumbleB
Forum Junior
Topics: 2
Posts: 83
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BTW...
from embryo prosencephalon = diencephalon + telencephalon
(which later develop into the cerebrum and cerebral hemispheres) - so in HPE this differentioation doesnt happen and brain has varying dfegrees of absence of the normal lobes...
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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Thanks once again bumblebee...you're the best!!OK now you're really freaking me out.....I never knew these things even existed!!Whats cyclopism???I never heard of it.Thanks once again....which university or if you don;t wish to reveal that which state/country are you studying in??
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