adeelmd
Forum Elite
Topics: 40
Posts: 401
|
25 year old male patient comes in with a fever of 102, cough, and chills. By what mechanism does IL-1 Act?
a) It indirectly leads to vasoconstriction
b) It has a direct affect on the temperature center in the thalamus
c) It increases secretion of TNF-A, which produces fever
d) It directly increases vascular permeability.
___________________
where i lay my head is home.
|
| Ahab
Forum Elite
Topics: 9
Posts: 228
|
b.
|
| adeelmd
Forum Elite
Topics: 40
Posts: 401
|
no
___________________
where i lay my head is home.
|
| Ahab
Forum Elite
Topics: 9
Posts: 228
|
Misread the question, thought it said hypothalamus
IL-1 acts on the hypothalamus to increase secretion of prostaglandins (E subtype) which change the set point for thermoregulation, the question becomes whether or not this is a direct effect or indirect through prostaglandins production. I would say direct effect as when IL-1 is released in high enough quantities it enters the circulation to physically interact with the hypothalamus and exert its effects.
as for c. my understanding is that while TNF-A does have pyrogenic effects it induces macrophages to secrete IL-1, not the other way around
|
| dariush
Forum Elite
Topics: 20
Posts: 356
|
i totally go along with Ahab.
___________________
Allah (God) is watching over us...
|
| mani
Forum Guru
Topics: 104
Posts: 1,403
|
i think there is one option missing and that is "increased prostaglandinds". i would go for that
___________________
Sincerity and hard work are the keys to success!
|
| adeelmd
Forum Elite
Topics: 40
Posts: 401
|
there is an answer cuz I made up this question so that I wouldn't forget this mechanism....
"IL 1 and TNF intereact with vascular receptors in the thermorefulatory centers of the hyupothalamus, inducing local prostagladin E2 production, resulting in sympathetic nerve stimulation, vasoconstriction of skin vessels, and fever"
Direct quote from pocket Robbins page 57...
___________________
where i lay my head is home.
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
adeelmd, u r right dat 'IL 1 and TNF intereact with vascular receptors in the thermorefulatory centers of the hyupothalamus, inducing local prostagladin E2 production'
PGE2 raises the thermostatic set pt in hypothalamus
To increase the temp(body needs to conserve energy)
vasoconstriction of skin vs-->dec loss of heat thru skin
shivering--->inc heat prodn(increased activity)
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
|
| |
| | | | | | | | |
