mash
Forum Fanatic
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hypoxia(deoxygenation causes sickling of rbcs in SCD)
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| Sakaki-
Forum Senior
Topics: 1
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The replacement with valine creates a hydrophobic contact point at position 6 of the beta chain such that the deoxygenated form is prone to forming strands and aggregating.
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| mjl1717
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Two main reasons for sickling or aggregates
1) As Mash says hypoxia or decrease O2 tension
2)**Increased Hemoglobin S
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| Malaysian
Forum Guru
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mjl1717.....isn't hypoxia when o2 tension is increased???
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